Cyprocide selectively kills nematodes via cytochrome P450 bioactivation

Cyprocide selectively kills nematodes via cytochrome P450 bioactivation

Blog Article

Abstract Left unchecked, plant-parasitic nematodes have the potential to toe straps devastate crops globally.Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation.Here, we report our discovery of a 1,3,4-oxadiazole thioether scaffold called Cyprocide that selectively kills nematodes including diverse species of plant-parasitic nematodes.

Cyprocide is bioactivated into a lethal reactive electrophilic metabolite by specific nematode cytochrome P450 enzymes.Cyprocide fails to kill organisms beyond nematodes, suggesting that the targeted lethality of this pro-nematicide derives from P450 substrate SOAP 3 IN 1 CITRUS selectivity.Our findings demonstrate that Cyprocide is a selective nematicidal scaffold with broad-spectrum activity that holds the potential to help safeguard our global food supply.